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Image Search Results
Journal: Alzheimer's & Dementia
Article Title: Cognitive resilience to Alzheimer's disease characterized by cell‐type abundance
doi: 10.1002/alz.14187
Figure Lengend Snippet: Overview of the study design. A, Cell fraction was calculated from 2457 bulk RNA‐seq samples from among three brain regions (AC, DLPFC, PCC) in the ROSMAP cohort using the DeTREM algorithm. B, Cell fractions in the remaining samples were compared to diagnostic categories and clinicopathological traits. C, Cell‐fraction quantitative trait locus analysis in samples with WGS data. AC, anterior caudate; AD, Alzheimer's disease; AST, astrocytes; DLPFC, dorsolateral prefrontal cortex; END, endothelial cells; MIC, microglia; ODC, oligodendrocytes; OPC, oligodendrocyte precursors; PCC, posterior cingulate cortex; ROSMAP, Religious Orders Study and Rush Memory and Aging Project; SWDBB, South West Dementia Brain Bank; WGS, whole genome sequencing.
Article Snippet: Data were preprocessed and analyzed using the TOPMed
Techniques: RNA Sequencing, Diagnostic Assay, Sequencing